The effect of Permixon on
androgen receptors.
Study
TITLE
The effect of Permixon on androgen
receptors.
AUTHOR
el-Sheikh MM; Dakkak MR; Saddique
A
ORGANISATION
Department of Obstetrics and
Gynaecology, King Khalid University Hospital, Riyadh, Saudi Arabia.
SOURCE
Acta Obstet Gynecol Scand 1988; 67 (5):
397-9
LANGUAGE OF
PUBLICATION
English
ABSTRACT
Permixon, the liposterolic extract of
the plant Serenoa Repens is a recently introduced drug for the treatment of
benign prostatic hyperplasia. The effect of Permixon on dihydrotestosterone and
testosterone binding by eleven different tissue specimens was tested. The drug
reduced the mean uptake of both hormones by 40.9% and 41.9% respectively in all
tissue specimens. Since hirsutism and virilism are among other gynecological
problems caused either by excessive androgen stimulation or excess endorgan
response, we suggest that Permixon could be a useful treatment in such
conditions and recommend further investigations of the possible therapeutic
values of the drug in gynecological practice. (AUTHOR)
MJTR: Androgen Antagonists PD. Plant
Extracts PD. Receptors, Steroid DE.
MNTR: Adult. Female. Human. Infant,
Newborn. Male. Stanolone ME. Tissue Distribution. JOURNAL ARTICLE
RNUM: 0 (testosterone receptor); 0
(Androgen Antagonists); 0 (Permixon); 0 (Plant Extracts); 0 (Receptors,
Steroid); 521-18-6 (Stanolone)
GEOT: SWEDEN
IDEN: ISSN: 0001-6349. JOURNAL-CODE:
1E8. ENTRY-DATE: 890303. JOURNAL-SUBSET: M. IM-DATE: 8905.
ACCE: 89115768
